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KMID : 0381920100400040245
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Korean Journal of Microscopy
2010 Volume.40 No. 4 p.245 ~ p.251
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Effect of Epidermal Changes in the Mice Skin Following Glycolic Acid Peeling
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Lee Jee-Yeon
Lee Suk-Jun
Chang Byung-Soo
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Abstract
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In this study, we applied 15% glycolic acid peeling agent and 30% glycolic acid peeling agent to the dorsal skin of mice and analyzed the oil content, moisture content, and pH value of the skin before and after test using cutometer. Ultrastructure for changes in the epidermis of mice were observed under a dermoscope and a scanning electron microscope before and after test. When using 15% glycolic acid peeling agent, the changes of moisture content was measured 74.67 AU for the normal control group and 70.21 AU for the experimental group, the oil content was 13.49 mg/cm2 for the normal control group before test and 8.25 mg/cm2 after test, and the pH value was 6.70 and 5.36 before and after test, respectively. When using 30% glycolic acid peeling agent, the moisture content was measured 74.46 AU for the normal control group before test and 53.50 AU for the experimental group after test, the oil content was 13.82mg/cm2 and 5.70 mg/cm2 before and after test, and the pH value was 6.45 and 4.58 before and after test, respectively. As such, it was found that the changes of moisture and oil content on the skin rely on the concentration of peeling agent and the degree of exfoliation of keratin. The surface of stratum corneum of mice with application of 15% glycolic acid peeling agent was relatively smooth and the exposed cellular surface of keratinocyte had some wrinkles. The surface of stratum corneum of mice with application of 30% glycolic acid peeling agent was smooth. No wrinkles were observed under high-resolution scanning electron microscope.
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KEYWORD
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Chemical peeling, Glycolic acid, Corneum, Keratin, Skin
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